Deep Brain Stimulation for Disorders of Addiction: Mechanisms and a Pilot Blinded Randomized Cross-over Placebo Controlled Trial
This study is testing whether deep brain stimulation (DBS) can safely help people with severe alcohol use disorder who have not improved with standard treatments. DBS uses small electrical signals to change activity in brain areas linked to craving, self-control, and emotion. The study will test whether this treatment can reduce how often people drink and how much they drink each day. Researchers will also record brain activity to better understand how DBS affects craving and relapse.
• Adults aged 18 to 60 years
• Diagnosed with Alcohol Use Disorder (AUD) according to DSM-5 criteria
• Primary diagnosis of treatment-refractory AUD (comorbid nicotine dependence, other psychoactive substance use disorders, moderate major depressive disorder, anxiety disorders or obsessive-compulsive disorder are permissible if AUD is principal)
• Disorder duration of AUD ≥ 5 years
• At least 3 unsuccessful attempts at achieving abstinence
• Failed prior psychotherapy and standard pharmacotherapy for AUD
• Medically and neurologically suitable for surgery and MRI-compatible
• Capable of providing informed consent and willing to comply with study procedures