Use of Probe-based Confocal Laser Endomicroscopy to Perform Targeted Optical Biopsy for Local Rectal Scars in Rectal Cancer Patients After Neoadjuvant Chemoradiotherapy

Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Currently, low concordance (36%) is found between clinical complete response and pathologic complete response in patients with rectal cancer after neoadjuvant chemoradiotherapy. Probe-based confocal laser endoscopy (pCLE) provides a promising targeted optical biopsy to evaluate the response to neoadjuvant chemoradiotherapy. The aim of this study is to investigate whether pCLE-targeted optical biopsy can improve the accuracy of preoperative endoscopic biopsy for local rectal scars in rectal cancer patients after neoadjuvant chemoradiotherapy.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 80
Healthy Volunteers: f
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• Age from over 18 to under 80 years

• American Society of Anesthesiology(ASA) score class I,II,or III

• Locally advanced rectal cancer

• Patient has completed standard neoadjuvant therapy

• Expected surgical resection

• Written informed consent

Locations
Other Locations
China
Nanfang Hospital, Southern Medical University
RECRUITING
Guangzhou
Contact Information
Primary
Jun Yan, M.D., Ph.D.
yanjunfudan@163.com
086-13825066546
Time Frame
Start Date: 2021-11-04
Estimated Completion Date: 2026-11-01
Participants
Target number of participants: 68
Treatments
Experimental: Endoscopic biopsy and probe-based confocal laser endomicroscopy biopsy
In this study , endoscopic biopsy and pCLE-targeted optical biopsy will be successively performed for local rectal scars in rectal cancer patients after neoadjuvant chemoradiotherapy.
Related Therapeutic Areas
Endoscopy
Colorectal Cancer
Sponsors
Leads: Nanfang Hospital, Southern Medical University

This content was sourced from clinicaltrials.gov

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