Colorectal Cancer Screening Cohort Study in Shougang Community Population Based on Polygene Methylation Detection Technology
Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY
This study will validate the real world results of polygene methylation detection in colorectal cancer in a large prospective community cohort. In this study, questionnaire survey and polygene methylation detection technology of colorectal cancer were used as preliminary screening methods, and colonoscopy was used as further validation examination method to screen colorectal cancer and precancerous lesions. The diagnosis and outcome of all lesions were based on colonoscopy and pathological examination.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 40
Healthy Volunteers: t
View:
• Chronological age ≥40 years;
• Full capacity for action;
• After enrollment, the participants were able to complete the Colorectal Cancer Risk Factor Assessment Questionnaire and the annual follow-up interviews;
• In the course of the study, the information related to tumor diagnosis in other hospitals can be timely fed back to the researchers;
Locations
Other Locations
China
Peking University Shougang Hospital
RECRUITING
Beijing
Contact Information
Primary
Jin Gu, Doctor
yuanping_632@163.com
010-57830127
Backup
Ping Yuan
15210919487
Time Frame
Start Date:2022-07-09
Estimated Completion Date:2028-07-09
Participants
Target number of participants:18000
Treatments
Positive group
All the subjects who completed colorectal cancer polygene methylation test at baseline completed colonoscopy within 3 months. Colorectal cancer diagnosed by colonoscopy, adenoma or polyp lesions found after treatment will reach the end of the study. The tumor history of family members was tracked for patients who met the end point of the study. The positive subjects who did not reach the end point of the study underwent three center visits at 12, 36 and 60 months after enrollment respectively, including history taking, colonoscopy, FIT test and blood CEA test. Another telephone follow-up was conducted at 24 and 48 months, respectively.
Negative group
The subjects who completed colorectal cancer polygene methylation test at baseline, and those with negative test results (n= 500, direct extraction method) completed colonoscopy within 3 months. The end points and follow-up were the same as those in the positive group. The negative group was compared with the positive group to observe the difference of negative predictive value and survival outcome.