Preoperative Dexmedetomidine Nebulization in Blunting Hemodynamic Stress Response to Laryngoscopy

Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 4
SUMMARY

The goal of this interventional study is to check the effectiveness of nebulized Dexmedetomidine in preventing the rise in blood pressure and heart rate in patients undergoing General Anesthesia. The study will be conducted in patients presenting for elective surgery either healthy or having co-existing medical conditions which affect their daily living to a moderate extent. These participants will require general anesthesia for their surgical procedure. General Anesthesia will make the patient unconscious, unable to breath and protect his airway. One way to provide airway and ventilatory support to such patient is by placing endotracheal tube into the patient's windpipe and for that direct laryngoscopy is performed. Direct laryngoscopy is one of the most painful stimulus a person can receive. Therefore like any other thing that causes pain it leads to a rise in blood pressure and heart rate. This can be harmful to the person suffering from cardiac disease. As a result one must blunt this painful response while providing adequate airway support to the patient needing General Anesthesia. There are number of drugs which can be used for this purpose. They can be given Intravenously or directly into the patient upper airway so that they can make the area numb. One of the drugs which is used for this purpose is Dexmedetomidine. In this study Dexmedetomidine will be nebulized and directly deliver to the patient's airway just like an asthmatic receives medication from inhaler devices. After giving sufficient time for drug to work, airway will be secured with endotracheal tube using direct laryngoscopy and the degree of rise in Blood Pressure and Heart rate of the patient will be observed. The results will be compared with a control group receiving a substance which looks like a drug but has no effects.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 16
Healthy Volunteers: t
View:

• Age: 16 years and above.

• American Society of Anesthesiologists (ASA) class: I, II and III.

• Elective surgeries under General Endotracheal Anesthesia.

• Potentially difficult airway.

Locations
Other Locations
Pakistan
Deparment of Anesthesia and Critical Care Medicine, Pakistan Institute of Medical Sciences
RECRUITING
Islamabad
Contact Information
Primary
Muhammad Haroon Anwar, MBBS
haroonanwar22@gmail.com
+92-333-5236956
Backup
Naheed Fatima, MBBS,FCPS
naheedfk73@gmail.com
+92-300-5236655
Time Frame
Start Date: 2023-11-21
Estimated Completion Date: 2024-12
Participants
Target number of participants: 126
Treatments
Experimental: Group Dexmedetomidine
This will be the intervention group. Patients entering this group through computer generated random numbers will receive nebulization Dexmedetomidine in the pre-operative area under the supervision of consultant anesthetist.
Placebo_comparator: Group Normal Saline
This will be the placebo or control group. Patients entering this group through computer generated random numbers will receive nebulization with Normal Saline (placebo) in the pre-operative area under the supervision of consultant anesthetist.
Related Therapeutic Areas
Sponsors
Leads: Muhammad Haroon Anwar
Collaborators: Pakistan Institute of Medical Sciences

This content was sourced from clinicaltrials.gov