The Role of Preoperative D-dimer Levels in the Diagnosis of Adnexal Torsion in Children and Adolescents

Status: Recruiting
Location: See all (9) locations...
Intervention Type: Diagnostic test
Study Type: Observational
SUMMARY

Adnexal torsion is the fifth most common gynecologic emergency. Thirty percent of all cases of adnexal torsion occur in females younger than 20 years. Approximately 5 of 100,000 females aged 1-20 years are affected, with girls older than 10 years at increased risk because of hormonal influences and gonadal growth that result in an increased frequency of physiologic and pathologic masses. The most common clinical symptom of torsion is sudden-onset abdominal pain that is intermittent, non-radiating, and associated with nausea and vomiting in 62% and 67% of cases respectively. Moreover, abdominal tenderness is a clinical sign which is reported in up to 88% of patients with adnexal torsion. None of the following tests are useful in the diagnosis of adnexal torsion: leukocytosis, pyuria, C-reactive protein, and erythrocyte sedimentation rate. Actually, transabdominal ultrasonography is the imaging modality of choice with a sensitivity of 92% and specificity of 96% in detecting adnexal torsion. A second-line imaging tool in the diagnosis of adnexal torsion is magnetic resonance, which may require a sedation in selected cases. Consequently, there are no clinical or imaging criteria sufficient to confirm the preoperative diagnosis of adnexal torsion to date. Therefore, patients with a clinical suspicion for adnexal torsion should undergo emergent diagnostic laparoscopy.

Eligibility
Participation Requirements
Sex: Female
Maximum Age: 17
Healthy Volunteers: f
View:

• Female patients

• Age \< 18 years

• presenting with lower quadrants abdominal pain

• Imaging suspicious for adnexal torsion

Locations
Other Locations
Austria
Medical University of Graz
RECRUITING
Graz
Medical University of Vienna
RECRUITING
Vienna
Italy
IRCCS Giannina Gaslini
RECRUITING
Genova
Azienda Ospedale Università Padova
RECRUITING
Padua
Fondazione IRCCS Policlinico San Matteo
RECRUITING
Pavia
Presidio Ospedaliero Santa Chiara
RECRUITING
Trento
Institute for Maternal and Child Health - IRCCS Burlo Garofolo
RECRUITING
Trieste
Serbia
University of Belgrade
RECRUITING
Belgrade
University of Novi Sad
RECRUITING
Novi Sad
Contact Information
Primary
Alessandro Boscarelli, MD
alessandro.boscarelli@burlo.trieste.it
+393931757607
Time Frame
Start Date: 2022-01-13
Estimated Completion Date: 2024-12-13
Participants
Target number of participants: 130
Treatments
Ovarian Torsion
All female patients under the age of 18 with suspicious signs and symptoms of ovarian torsion
Sponsors
Leads: IRCCS Burlo Garofolo

This content was sourced from clinicaltrials.gov