Impact of Recruitment Maneuvers and PEEP-guided Electrical Impedance Tomography on Regional Ventilation, Gas Exchange, and Pulmonary Mechanics in in Abdominal Laparoscopic Surgery Patients

Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Abdominal laparoscopy is widely utilized due to its benefits, including minimal invasiveness, improved cosmetic outcomes, and shorter hospital stays. However, the use of intraoperative pneumoperitoneum and general anesthesia with mechanical ventilation may lead to postoperative pulmonary complications, such as atelectasis. This condition can result in diminished respiratory mechanics and impaired gas exchange. In recent years, intraoperative lung-protective mechanical ventilation techniques, including recruitment maneuvers (RMs) and positive end-expiratory pressure (PEEP) strategies, have gained popularity. These approaches aim to prevent the repeated collapse and reopening of alveoli, thereby reducing the risk of atelectasis. Nonetheless, determining the optimal PEEP level for individual patients remains a complicated and unresolved issue. Electrical impedance tomography (EIT) is a bedside imaging technique that assesses regional ventilation distribution, providing a method for personalizing PEEP settings in mechanically ventilated patients. By addressing the competing risks of alveolar overdistension and collapse, EIT enhances the precision of PEEP titration. This study aims to compare the effects of recruitment maneuvers and EIT-guided PEEP selection against conventional ventilation on regional ventilation, gas exchange, and pulmonary mechanics in patients undergoing abdominal laparoscopic surgery.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Age \> 18 years

• Scheduled for abdominal laparoscopy surgery

• At increased (i.e., intermediate or high) risk of postoperative pulmonary complications according to the Assess Respiratory Risk in Surgical Patients in Catalonia (ARISCAT) score (≥ 26 points)

• Signed written informed consent

Locations
Other Locations
Viet Nam
Anesthesia Center, Bach Mai Hospital
RECRUITING
Hanoi
Contact Information
Primary
Thanh Huyen Thi Pham, M.D
drthanhhuyen368@gmail.com
+84989733699
Time Frame
Start Date: 2024-08-01
Estimated Completion Date: 2025-12-30
Participants
Target number of participants: 70
Treatments
Active_comparator: Intervention Group
Patients were applied recruitment maneuvers and EIT-guided PEEP during ventilation during general anesthesia.
Placebo_comparator: Control Group
Patients will receive a constant PEEP of 5 cm H2O without RMs throughout the entire intraoperative ventilation period
Related Therapeutic Areas
Sponsors
Collaborators: Hanoi Medical University, Bach Mai Hospital
Leads: Nguyen Dang Thu

This content was sourced from clinicaltrials.gov