Application of Remimazolam Combined With Esketamine in Painless Gastroscopy and Colonoscopy in Elderly Patients

Status: Recruiting
Location: See location...
Intervention Type: Combination product
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The objective of this clinical trial is to assess the feasibility of the remimazolam combined with esketamine OFA (opioid-free anesthesia) protocol for painless gastroscopy and colonoscopy in elderly patients and to determine if it is non-inferior to the traditional OA (opioid-containing anesthesia) protocol. The main questions it aims to answer are: * Is the remimazolam combined with esketamine protocol feasible for painless gastroscopy and colonoscopy in elderly patients? * Is the OFA protocol superior to the OA protocol? Participants will: * During anesthesia induction, the experimental group will receive remimazolam combined with esketamine for anesthesia, while the control group will receive remimazolam combined with remifentanil. * Record respiratory and circulatory indicators and adverse reaction times.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 65
Healthy Volunteers: f
View:

• Patients undergoing painless gastroenteroscopy in outpatient clinics;

• aged 65 years and above;

• American Society of Anesthesiologists (ASA) grades I - III.

Locations
Other Locations
China
The First Affiliated Hospital of Harbin Medical University
RECRUITING
Harbin
Contact Information
Primary
LIU Shujie LIU
shujieliu312@163.com
+86 138 4508 0390
Backup
SHI Xiaoqian SHI
shixiaoqian005@163.com
+86 188 3424 7923
Time Frame
Start Date: 2025-03-14
Estimated Completion Date: 2028-01
Participants
Target number of participants: 280
Treatments
Experimental: remimazolam plus esketamine group
Esketamine combined with remimazolamwas used for anesthesia.
Active_comparator: remimazolam plus remifentanil group
Remifentanil combined with remimazolam was used for anesthesia.
Related Therapeutic Areas
Sponsors
Collaborators: First Affiliated Hospital of Harbin Medical University
Leads: Harbin Medical University

This content was sourced from clinicaltrials.gov