Series Study on the Application of G Protein-Biased Receptor Agonist Oliceridine in Gynecological Surgery (2):Effects of Oliceridine Versus Sufentanil on Postoperative Nausea and Vomiting After Gynecological Laparoscopic Surgery

Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 4
SUMMARY

The aim of this clinical trial is to evaluate the impact of the analgesic Oliceridine on postoperative nausea and vomiting (PONV) following gynecological laparoscopic surgery. It will also assess the safety profile of Oliceridine. The trial seeks to address the following key questions: Can Oliceridine reduce the incidence of postoperative nausea and vomiting (PONV) in gynecological laparoscopic surgery? Does the incidence of PONV differ between patients receiving Oliceridine and those receiving the commonly used analgesic sufentanil in gynecological laparoscopic surgery? Are there any opioid-related adverse reactions in gynecological laparoscopic surgery patients using Oliceridine? Participants will: Receive Oliceridine or sufentanil for anesthesia induction, maintenance, and postoperative pain management. Vital signs during surgery and the occurrence of postoperative nausea and vomiting will be recorded. Be followed up for at least 48 hours.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 65
Healthy Volunteers: f
View:

• Elective gynecological laparoscopic surgery;

• Age 18-65 years;

• ASA physical status I-III;

• Body mass index (BMI) 18-30 kg/m².

Locations
Other Locations
China
The Second Xiangya Hospital of Central South University
RECRUITING
Changsha
Contact Information
Primary
Yanying Xiao, Doctor
xiaoyanying192@csu.edu.cn
+8613467609491
Backup
Yaping WANG, Doctor
wangyaping6568@csu.edu.cn
+8613607314476
Time Frame
Start Date: 2025-07-21
Estimated Completion Date: 2026-01-31
Participants
Target number of participants: 96
Treatments
Experimental: Oliceridine group
Anesthesia and analgesia with Oliceridine
Other: Sufentanil group
Anesthesia and analgesia with sufentanil
Related Therapeutic Areas
Sponsors
Leads: YanYing Xiao

This content was sourced from clinicaltrials.gov