Total Intravenous Anesthesia (TIVA), Combined Intravenous-Volatile Anesthesia (CIVA), and Balanced Anesthesia (BAL) on Perioperative Oxidative Stress in Video-Assisted Thoracoscopic Surgery (VATS)
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
The primary objective of our study is to compare the effects of total intravenous anesthesia (TIVA), combined intravenous-volatile anesthesia (CIVA), and balanced anesthesia (BAL) methods on perioperative oxidative stress parameters, such as Malondialdehyde (MDA), Total Oxidant Status (TOS), Total Antioxidant Status (TAS), and Superoxide Dismutase (SOD), in patients undergoing video-assisted thoracoscopic surgery (VATS). The secondary objective is to record perioperative vital parameters, arterial blood gas values obtained at specific stages of the surgery, and the incidence of postoperative nausea and vomiting (PONV).
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 65
Healthy Volunteers: f
View:
• Aged between 18 and 65 years,
• American Society of Anesthesiologists (ASA) Physical Status Class I-II,
• Scheduled for elective Video-Assisted Thoracoscopic Surgery (VATS)
• Requiring one-lung ventilation for more than 60 minutes
Locations
Other Locations
Turkey
Ataturk University
RECRUITING
Erzurum
Contact Information
Primary
Elif Oral Ahiskalioglu, Professor
drelforl@hotmail.com
+90-505-925-96-32
Backup
Mehmet Z Guney, MD
gnyzbyr@gmail.com
+90-541-718-34-25
Time Frame
Start Date:2025-12-01
Estimated Completion Date:2026-05-02
Participants
Target number of participants:60
Treatments
Experimental: Total Intravenous Anesthesia (TIVA) Group
Anesthesia induction will include 2 mg midazolam, 2-2.5 mg/kg propofol, 0.6-0.9 mg/kg rocuronium, and 1 μg/kg remifentanil. Maintenance will be provided with target-controlled infusion (TCI) propofol at a Ce of 4-6 μg/mL and TCI remifentanil at a Ce of 1.5-3 ng/mL while maintaining the bispectral index (BIS) between 40-60.
Experimental: Balanced Anesthesia (BAL) Group
Induction will follow the same protocol as the TIVA group. During maintenance, desflurane 5-7% (MAC 1-1.3) and TCI remifentanil at a Ce of 1.5-3 ng/mL will be administered, targeting a BIS value between 40-60.
Experimental: Combined Intravenous Volatile Anesthesia (CIVA) Group
Induction will follow the same protocol as other groups. Maintenance will include TCI propofol at a Ce of 2-4 μg/mL and TCI remifentanil at a Ce of 1.5-3 ng/mL along with 3% desflurane (MAC 0.5), keeping BIS values between 40-60.