• Patients\>18 years of age undergoing endoscopy for any of the following indications:

⁃ Indications for Tissue Apposition:

• Closure of perforations

• Closure of full thickness defects created during endoscopic full thickness resection

• Closure of defects after endoscopic submucosal dissection and endoscopic mucosal resection

• Closure of mucosotomy after Peroral Endoscopic Myotomy (POEM)

• Stent fixation

• Closure of fistulas

• Natural Orifice Transluminal Endoscopic Surgery defect closures

• Post-bariatric surgery gastrojejunal anastomosis and gastric pouch revision (transoral outlet repair)

• Primary endoscopic sleeve gastroplasty