Effects of Sevoflurane, Desflurane or Propofol Anesthesia on High-Dose Rocuronium in Laparoscopic Cholecystectomy Operations
Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY
This study evaluates the effects of three different anesthetics on high dose rocuronium in laparoscopic cholecystectomy cases. Patients were randomly assigned to one of the propofol, desflurane, or sevoflurane groups. Train of four (TOF) and bispectral index (BIS) monitoring were used during surgery in all groups.Patients were followed until TOF and post tetanic count (PTC) values reached 1 and the time was recorded.The effect of three anesthetic drugs used on the duration of the muscle relaxant drug was investigated.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 65
Healthy Volunteers: f
View:
• American Society of Anesthesiology (ASA) Ⅰ-Ⅲ patients
• between the ages of 18-65
Locations
Other Locations
Turkey
Hatay Mustafa Kemal University
RECRUITING
Antakya
Contact Information
Primary
Selim Turhanoglu, MD
adat63@gmail.com
+905325062988
Backup
Menekşe Okşar, MD
menekseoksar@gmail.com
+905337108301
Time Frame
Start Date: 2023-10-02
Estimated Completion Date: 2024-09-02
Participants
Target number of participants: 75
Treatments
S(Sevoflurane)
Anesthesia induction for all patients will be performed with 2 mg/kg propofol and 2 µg/kg fentanyl. Following loss of eyelash reflex, 1.2 mg/kg rocuronium will be administered intravenously to all patients. Anesthesia will be maintained with sevoflurane, with a BIS value between 40-50 and a minimal alveolar concentration (MAC) value between 1-1.5.
D(Desflurane)
Anesthesia induction for all patients will be performed with 2 mg/kg propofol and 2 µg/kg fentanyl. Following loss of eyelash reflex, 1.2 mg/kg rocuronium will be administered intravenously to all patients. Anesthesia will be maintained with desflurane, with a BIS value between 40-50 and a MAC value between 1-1.5.
P(Propofol)
Anesthesia induction for all patients will be performed with 2 mg/kg propofol and 2 µg/kg fentanyl. Following loss of eyelash reflex, 1.2 mg/kg rocuronium will be administered intravenously to all patients. Propofol was administered intravenously at a rate of 6-12 mg/kg/min to maintain anesthesia, keeping the BIS value between 40-50.
Related Therapeutic Areas
Sponsors
Leads: Mustafa Kemal University