Oral Dexamethasone at Night to Prevent Postoperative Nausea and Vomiting After Laparoscopic Cholecystectomy: A Protocol for Randomized Clinical Trial
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 3
SUMMARY
Postoperative nausea and vomiting (PONV) are common complications after laparoscopic cholecystectomy. This study aims to evaluate the efficacy of the administration of prophylactic oral dexamethasone at night before surgery in preventing PONV after elective laparoscopic cholecystectomy.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• all consecutive adults (older than 18 years) with ASA physical status I-III undergoing elective laparoscopic cholecystectomy surgery.
Locations
Other Locations
Egypt
Mansoura University Faculty of Medicine
RECRUITING
Al Mansurah
Contact Information
Primary
Moataz M Emara, MD, EDAIC
mm.emara@mans.edu.eg
+201064048848
Time Frame
Start Date: 2024-03-04
Estimated Completion Date: 2025-03
Participants
Target number of participants: 814
Treatments
Experimental: At-night oral dexamethasone
Patients in the intervention group will receive oral 8 mg dexamethasone at night before surgery. The time of dexamethasone administration will be recorded.
Active_comparator: At-induction dexamethasone
Patients in the control group will receive intravenous 8 mg dexamethasone just before or at the induction of anesthesia. The dexamethasone ampule will be diluted in a 10 ml syringe and given in at least one minute to avoid unpleasant sensations in injection.
Related Therapeutic Areas
Sponsors
Leads: Mansoura University