Preoperative and Postoperative Erector Spinae Plane Block: Effects on Frontal QRS-T Angle in Laparoscopic Surgery - A Prospective Randomized Study

Status: Recruiting
Location: See location...
Intervention Type: Procedure, Drug
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This study aims to investigate the effects of preoperative and postoperative Erector Spinae Plane (ESP) block on the frontal QRS-T angle, a marker of cardiac electrophysiological instability, in patients undergoing laparoscopic cholecystectomy. A total of 120 patients aged 18-65 with ASA I-II status will be randomized into three groups: Control (no ESP), Preoperative ESP, and Postoperative ESP. Electrocardiograms (ECGs) will be obtained preoperatively and one hour postoperatively to assess changes in QRS-T angle and other repolarization parameters. This randomized controlled trial will help clarify the potential cardiac effects of ESP block depending on its timing and may provide insight into optimizing anesthetic safety in surgical patients.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 65
Healthy Volunteers: f
View:

• Age between 18-65 years

• ASA physical status I-II

• Scheduled for elective laparoscopic cholecystectomy

• Voluntary written informed consent obtained

• Normal preoperative 12-lead ECG (no conduction abnormalities or arrhythmias)

Locations
Other Locations
Turkey
Veli Fahri Pehlivan
RECRUITING
Sanliurfa
Contact Information
Primary
Veli F Pehlivan, Asiss Prof
vfpehlivan@harran.edu.tr
05327696566
Backup
Basak pehlivan, Prof Dr
bpehlivan@harran.edu.tr
05054083194
Time Frame
Start Date: 2025-07-20
Estimated Completion Date: 2025-10-03
Participants
Target number of participants: 120
Treatments
Experimental: Preoperative ESP Block Group
Patients in this group will receive bilateral ultrasound-guided erector spinae plane (ESP) block at the T7 level with 20 mL of 0.25% bupivacaine on each side (total 40 mL) before the induction of general anesthesia. ECG will be recorded preoperatively and at 1 hour postoperatively. Frontal QRS-T angle, QT interval, QTc, Tp-e interval, and Tp-e/QTc ratio will be analyzed.
Experimental: Postoperative ESP Block Grou
Patients in this group will undergo standard general anesthesia. At the end of surgery, bilateral ESP block will be applied at the T7 level using 20 mL of 0.25% bupivacaine per side. ECG will be taken preoperatively and at 1 hour after surgery to evaluate changes in cardiac electrophysiologic parameters including the Frontal QRS-T angle.
Active_comparator: Control Group (No ESP Block)
Patients in the control group will receive standard general anesthesia only, without any regional block. Preoperative and 1-hour postoperative ECGs will be obtained for comparison of electrophysiologic markers such as Frontal QRS-T angle, QT, QTc, Tp-e, and Tp-e/QTc.
Sponsors
Leads: Harran University

This content was sourced from clinicaltrials.gov