Laparoscopic Cholecystectomy Patients: Effect of Sevoflurane vs. Desflurane on Mechanical Power - A Prospective, Randomized, Controlled Trial
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
This single-center, prospective, randomized, assessor-blinded clinical trial aims to compare the effects of sevoflurane and desflurane anesthesia on intraoperative mechanical power in adult patients undergoing elective laparoscopic cholecystectomy. Mechanical power will be measured at three standardized time points using a validated formula, and secondary outcomes include driving pressure values and early postoperative respiratory complications (desaturation, laryngospasm, bronchospasm, cough).
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 65
Healthy Volunteers: f
View:
• Adults aged 18-65 years
⁃ ASA Physical Status I-II
⁃ Scheduled for elective laparoscopic cholecystectomy
⁃ Able to provide written informed consent
Locations
Other Locations
Turkey
Konya City Hospital
RECRUITING
Konya
Contact Information
Primary
Nuran AKINCI EKİNCİ
nurandr@yahoo.com
+905337637180
Backup
Esma Karaarslan
+905057317061
Time Frame
Start Date: 2026-03-09
Estimated Completion Date: 2026-05-30
Participants
Target number of participants: 138
Treatments
Experimental: Arm S- Sevoflurane Group
Maintenance of general anesthesia with sevoflurane 2% during laparoscopic cholecystectomy. Mechanical power is measured at three intraoperative time points using standardized ventilator settings.
Experimental: Arm D-desflurane group
Maintenance of general anesthesia with desflurane 6% during laparoscopic cholecystectomy. Mechanical power is measured at three standardized intraoperative time points under identical ventilator settings.
Related Therapeutic Areas
Sponsors
Leads: Konya City Hospital