Impact of Menstrual Phases and Menopause on Intraoperative Anesthetic Consumption and Postoperative Nausea and Vomiting: A Prospective Observational Study
Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY
This prospective observational cohort study aims to evaluate the association between menstrual phase (determined by postoperative serum progesterone levels), intraoperative anesthetic consumption, and the incidence and severity of postoperative nausea and vomiting (PONV) in female patients undergoing cholecystectomy. Intraoperative anesthetic requirements will be recorded, and postoperative nausea and vomiting will be assessed using standardized scoring systems.
Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Maximum Age: 65
Healthy Volunteers: f
View:
• Female patients aged 18 to 65 years
• American Society of Anesthesiologists (ASA) physical status I-II-III
• Scheduled for elective laparoscopic cholecystectomy under general anesthesia
• Willing and able to provide written informed consent
Locations
Other Locations
Turkey
Ankara Etlik City Hospital
RECRUITING
Ankara
Contact Information
Primary
oya Çimen, Specialist in Anesthesiology
oya.cimen@hotmail.com
+905334494750
Backup
Fethi Gültop, Specialist in Anesthesiology
fethigultop@yahoo.com
+905052260067
Time Frame
Start Date: 2026-03-07
Estimated Completion Date: 2026-06-15
Participants
Target number of participants: 120
Treatments
Follicular Phase Group
Female patients undergoing cholecystectomy under general anesthesia who are classified as being in the follicular phase of the menstrual cycle based on postoperative serum progesterone levels. No experimental intervention will be applied. Intraoperative anesthetic consumption and postoperative nausea and vomiting will be recorded as part of routine perioperative management.
Luteal Phase Group
Female patients undergoing cholecystectomy under general anesthesia who are classified as being in the luteal phase of the menstrual cycle according to postoperative serum progesterone levels. No intervention beyond standard clinical care will be performed. Anesthetic drug consumption and postoperative nausea and vomiting outcomes will be documented.
Postmenopausal Group
Female patients undergoing cholecystectomy under general anesthesia who are postmenopausal. These patients will receive standard perioperative care. Intraoperative anesthetic requirements and postoperative nausea and vomiting will be assessed and compared with other hormonal status groups.
Related Therapeutic Areas
Sponsors
Leads: Ankara Etlik City Hospital