Pharmacokinetics and Responses to Alcohol After Bariatric Surgery
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Observational
SUMMARY
The goal of this observational study is to learn how the body processes ingested alcohol and how alcohol affects mood and blood sugar in both men and women after undergoing sleeve gastrectomy. The main question\[s\]it aims to answer are: * Are there differences in the way that ingested alcohol is handled in men versus women after sleeve gastrectomy? * What is the consequence of drinking alcohol on an empty stomach versus after a meal on blood sugar control after undergoing sleeve gastrectomy? Participants will participate in two types of alcohol tests (alcohol given orally or administered intravenously) after not eating anything overnight or after having a meal. Researchers will compare men and women who underwent sleeve gastrectomy with men and women who had no surgery, are of similar age and body composition, and have similar alcohol intake patterns.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 21
Maximum Age: 64
View:
• Surgery groups:
‣ Male and female, 21-64 yrs. of age
⁃ Drink at least 1 standard drink per month but no more than 7 per week (women or \> 14 for men)
⁃ Underwent SG surgery 1-5 years ago
∙ Non-surgery control group
• Male and female who did not undergo bariatric surgery
• Age , BMI, race , and alcohol pattern of consumption equivalent to participants in the SG surgery groups
Locations
United States
Illinois
University of Illinois at Urbana Champaign
RECRUITING
Urbana
Contact Information
Primary
Rafael Guimaraes de Lima, PhD
rafael5@illinois.edu
217-300-2374
Backup
Rafael Guimaraes de Lima, PhD
rafael5@illinois.edu
217-300-4709
Time Frame
Start Date:2024-07-31
Estimated Completion Date:2028-08
Participants
Target number of participants:88
Treatments
Women 1-5 years post-SG
* Alcohol orally administered (0.5 grams per kg of Fat-free mass) after overnight fast or after a standard meal~* Alcohol administered IV using an alcohol clamp (target concentration of 0.6g/L after an overnight fast or one hour after consuming a standard mixed meal)
Men 1-5 years post-SG
* Alcohol orally administered (0.5 grams per kg of Fat-free mass) after overnight fast or after a standard meal~* Alcohol administered IV using an alcohol clamp (target concentration of 0.6g/L after an overnight fast or one hour after consuming a standard mixed meal)
Women, non-operated control
* Alcohol orally administered (0.5 grams per kg of Fat-free mass) after overnight fast or after a standard meal~* Alcohol administered IV using an alcohol clamp (target concentration of 0.6g/L after an overnight fast or one hour after consuming a standard mixed meal)
Men, non-operated control
* Alcohol orally administered (0.5 grams per kg of Fat-free mass) after overnight fast or after a standard meal~* Alcohol administered IV using an alcohol clamp (target concentration of 0.6g/L after an overnight fast or one hour after consuming a standard mixed meal)