Observational Prospective Cohort Study on Hyperthermic Intraperitoneal Chemoperfusion (HIPEC) in Gastric Cancer
Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Observational
SUMMARY
The study investigates the outcomes of hyperthermic intraperitoneal chemoperfusion (HIPEC) in combination with curative-intent gastrectomy in resectable locally-advanced and limited-metastatic (low peritoneal cancer index) gastric cancer.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 80
Healthy Volunteers: f
View:
• Age 18-80
• Hystologicaly proven gastric adenocarcinoma
• ECOG status 0-1
• Written consent to participate in the study
• Medically and technically operable gastric tumor
• Only T4a or T4b tumours with any peritoneal cytology status
• Cytologically positive peritoneal washings (cyt+) with any T and N criteria
• Adequate haemopoetic, renal and hepatic function (Hb \> 120, PLT \> 150\*10\^9/l, ALT \< 60, AST \<40, total bilirubin \< 21 µmol/l, Creatinine clearance (male - 90-140, female - 80-130 ml/min)
Locations
Other Locations
Ukraine
National Cancer Institute (NCI)
RECRUITING
Kyiv
Contact Information
Primary
Oleksiy Dobrzhanskyi, MD
alekseydobrzhanskiy@gmail.com
+380638760185
Time Frame
Start Date: 2025-12-01
Estimated Completion Date: 2035-12-01
Participants
Target number of participants: 200
Treatments
Prophylactic cohort (T4a/T4b/cyt+)
The cohort consists of individuals undergoing gastrectomy along with HIPEC.
Low PCI cohort (PCI<7)
Patients with low PCI undergo curative surgery with cytoreduction of visually detected peritoneal nodules followed by HIPEC
Related Therapeutic Areas
Sponsors
Leads: Ukrainian Society of Clinical Oncology