Long-term Remote Ischemic Preconditioning Improves Myocardial Perfusion and Prognosis of Patients After Coronary Artery Bypass Grafting

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Remote Ischemic preconditioning (RIPC) has been reported to improve myocardial microcirculation, promote collateral circulation recruitment, and improve myocardial perfusion in patients.Two large randomized controlled trials demonstrated a perioperative cardioprotective effect of RIPC (reduced troponin levels), but did not find that a single preoperative RIPC improved long-term outcomes of coronary artery bypass grafting(CABG).The effect of a single RIPC before CABG may be too short. This study aims to investigate whether long-term RIPC improved myocardial perfusion in patients 3 months and 6 months after CABG surgery , and to detect changes in blood vascular endothelial growth factor, Nitrc Oxide, adenosine,and Endothelin-1, and to observe MACCE event rates at 12 months.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 80
Healthy Volunteers: f
View:

• Three coronary artery lesions, CABG surgery was planned

Locations
Other Locations
China
Fuwai central China cardiovascular Hospital
RECRUITING
Zhengzhou
Contact Information
Primary
Quan Guo, MD
xinyiguoquan@163.com
+8615670510031
Time Frame
Start Date: 2021-03-10
Estimated Completion Date: 2026-12-01
Participants
Target number of participants: 210
Treatments
Experimental: Experimental Group 1
Routine treatment + interventions:The patient underwent one RIPC (Four five-minute cycles of upper limb ischaemia and Four five-minute pauses using a blood pressure cuff air vehicle to 200 mmHg) before surgery, then normal surgery, and RIPC was performed on the second day and Once RIPC/day after CABG for one year.
Experimental: Experimental Group 2
Routine treatment + interventions:Patients underwent a RIPC before surgery, and then normal medical procedures were performed with no additional intervention.
No_intervention: Control group
routine treatment, no RIPC
Authors
Sponsors
Leads: Henan Institute of Cardiovascular Epidemiology

This content was sourced from clinicaltrials.gov