On-pump Versus Off-pump Coronary Artery Bypass Grafting , Short Term Outcomes , Sohag Experience

Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Coronary artery disease (CAD) and its sequlae, such as myocardial infarction, arrhythmia and heart failure, are among the leading causes of death around the world . the durable role of coronary artery bypass grafting (CABG) in the treatment of CAD has long been shown. Coronary artery bypass grafting (CABG) is a commonly performed surgical procedure for patients with coronary artery disease (CAD), CABG can be performed using either the on-pump or off-pump technique, each with its own advantages and limitations. On-pump CABG involves the use of CPB which as agold standard for surgical coronary revascularization has led toexcellent results in mortality and complications. On-pump CABG allows the surgeon to temporarily stop the heart and provide perfusion and oxygenation to the body. This technique provides a bloodless and motionless operative field, allowing for precise graft anastomosis. However, the use of CPB is associated with deleterious effects as systemic inflammatory response, hemodilution, and organ dysfunction as dysrhythmia and neurocognitive problems. These factors may adversely affect patients lives specially those with impaired EF, who already have compromised cardiovascular function. Another technique for CABG is on-pump beating heart CABG (ONBH-CABG) surgery that is relatively novel hybrid approach to coronary artery grafting which aims to stabilize hemodynamic parameters during the operative period. This has specific benefits such as reduced preload alongside the afterload which decreases the oxygen demand of the myocardial tissue

Eligibility
Participation Requirements
Sex: All
Healthy Volunteers: f
View:

• fair and impaired EF

Locations
Other Locations
Egypt
Sohag university Hospital
RECRUITING
Sohag
Contact Information
Primary
zeyad e ahmad, assistant lecutrer
Ziad.assem@med.sohag.edu.eg
01021301690
Backup
ayman M abdel gaffar
Time Frame
Start Date: 2023-07-10
Estimated Completion Date: 2024-07-10
Participants
Target number of participants: 120
Treatments
Active_comparator: on pump CABG
using cardiopulmonary bypass
Active_comparator: off pump CABG
without cardiopulmonary bypass
Sponsors
Leads: Sohag University

This content was sourced from clinicaltrials.gov