Predictive Modelling of Clinically Significant Depressive Symptoms After Coronary Artery Bypass Graft Surgery

Status: Recruiting
Location: See all (2) locations...
Study Type: Observational
SUMMARY

The primary goal of this project is to develop a predictive model for clinically significant depressive symptoms (CSDS) in patients undergoing coronary artery bypass graft (CABG) surgery, using pre- and perioperative data. CSDS occur in about 30 percent of CABG patients, which is four times higher than in the general population. These symptoms are linked to poor quality of life and increased morbidity and mortality. The aim is to create a model that can identify patients at risk for postoperative depression. This tool could help clinicians make informed decisions and take preventive measures to manage depression after surgery.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 90
View:

• Elective Off-Pump CABG or CABG, either isolated or combined with valve intervention

• Men and women, aged between 18 and 90 years

• Sufficient knowledge of German language in reading and understanding

• Oral and Signed consent form

• Ability and Willingness to follow the study protocol

Locations
Other Locations
Switzerland
Stadtspital Zürich (City Hospital Zurich) Triemli
RECRUITING
Zurich
University Hospital Zurich (USZ)
NOT_YET_RECRUITING
Zurich
Contact Information
Primary
Roland v Känel, Prof. Dr.
roland.vonkaenel@usz.ch
+41 (0)44 255 52 51
Backup
Sinthujan Sivakumar, MSc
sinthujan.sivakumar@usz.ch
+41 (0)44 255 35 95
Time Frame
Start Date: 2024-11-25
Estimated Completion Date: 2027-08-31
Participants
Target number of participants: 300
Treatments
Training group
From the final cohort of 300 participants, 200 will be recruited at Hospital I (University Hospital Zurich) to form the training group for developing the optimal statistical model.
Test group
From the final cohort of 300 participants, the remaining 100 will be recruited at Hospital II (Stadtspital Zurich Triemli) to form the test group for validating the final model.
Sponsors
Leads: Roland von Känel
Collaborators: Triemli Hospital, ETH Zurich, University of Zurich

This content was sourced from clinicaltrials.gov