The Effect of Low Tidal Volume Ventilation on Diaphragmatic Excursion in Cardiopulmonary Bypass Surgery

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goal of this clinical trial is to evaluate whether low tidal volume (LTV) ventilation during cardiopulmonary bypass (CPB) surgery helps preserve diaphragmatic excursion in adult patients undergoing coronary artery bypass grafting (CABG). The study will also assess the relationship between LTV ventilation and postoperative pulmonary complications, such as atelectasis, pleural effusion, and pneumonia. The main questions this trial aims to answer are: Does LTV ventilation better preserve diaphragmatic motion compared to apnea during CPB? Are postoperative pulmonary complications less frequent in patients receiving LTV? Does LTV contribute to shorter extubation times and ICU stays? Researchers will compare LTV ventilation with apnea (standard care) during CPB to assess its effects on diaphragmatic excursion, measured via ultrasound, and postoperative respiratory outcomes. Participants will: Undergo elective CABG surgery under general anesthesia Be randomly assigned to receive either LTV ventilation or apnea during CPB Have diaphragmatic excursion measured by ultrasound before surgery, before extubation, and 24 hours after surgery Be monitored for postoperative pulmonary complications (atelectasis, effusion, pneumonia), extubation time, and ICU length of stay Ultrasound will be used to measure diaphragmatic excursion (DE) in quiet and deep breathing. DE below 10 mm will be considered as diaphragmatic paralysis. Postoperative respiratory assessments will include blood gas analysis (PaO₂/FiO₂ ratio), clinical respiratory parameters, and imaging findings. This is a prospective, single-center, assessor-blinded randomized controlled trial. Patients and outcome assessors will be blinded to group allocation. The study will be conducted at the Anesthesiology Clinic of Konya City Hospital and is expected to enroll 60 patients.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 75
Healthy Volunteers: f
View:

• Age over 18 years

• Male or female patients

• American Society of Anesthesiologists (ASA) physical status class II or III

• Scheduled for elective coronary artery bypass graft (CABG) surgery with cardiopulmonary bypass (CPB)

• Provided written informed consent to participate in the study -

Locations
Other Locations
Turkey
Konya City Hospital
RECRUITING
Konya
Contact Information
Primary
Nuran AKINCI EKİNCİ, MD, anesthesiologist
nurandr@yahoo.com
+905337637180
Time Frame
Start Date: 2025-07-01
Estimated Completion Date: 2025-11-30
Participants
Target number of participants: 60
Treatments
Experimental: Group Low
Low Tidal Volume Ventilation Group (LTV)
No_intervention: Group Apnea
Apnea Group (Control Group)
Sponsors
Leads: Konya City Hospital

This content was sourced from clinicaltrials.gov

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