Desflurane vs. Propofol for Cardiac Anesthesia: Impact on Developing Major Cardiac Events in Patients Undergoing CABG Procedure
Status: Recruiting
Location: See all (14) locations...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 3
SUMMARY
To investigate whether the inhaled anesthetic desflurane, compared with propofol, exerts cardioprotective effects and reduces the incidence of severe postoperative major cardiac events in patients undergoing coronary artery bypass graft (CABG) surgery.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Patients scheduled for elective coronary artery bypass grafting (CABG)
• Age ≥ 18 years old;
• Sign the informed consent form.
Locations
Other Locations
China
Cangzhou People's Hospital
NOT_YET_RECRUITING
Cangzhou
Sichuan Provincial People's Hospital
NOT_YET_RECRUITING
Chengdu
Daping Hospital, Army Medical University
NOT_YET_RECRUITING
Chongqing
Fuzhou University Affiliated Provincial Hospital
NOT_YET_RECRUITING
Fuzhou
Jiangsu Province Hospital
NOT_YET_RECRUITING
Nanjin
Ningbo No.2 Hospital
NOT_YET_RECRUITING
Ningbo
Changhai Hospital
RECRUITING
Shanghai
Zhongshan Hospital, Fudan University
NOT_YET_RECRUITING
Shanghai
Hebei General Hospital
NOT_YET_RECRUITING
Shijiazhuang
The First Hospital of Hebei Medical University
NOT_YET_RECRUITING
Shijiazhuang
Tianjin Chest Hospital
RECRUITING
Tianjin
Wuhan Asia Heart Hospital
NOT_YET_RECRUITING
Wuhan
Xijing Hospital
RECRUITING
Xi'an
The First Affiliated Hospital of Zhengzhou University
NOT_YET_RECRUITING
Zhengzhou
Contact Information
Primary
Chong Lei, M.D.& phd
crystalleichong@126.com
18629011362
Time Frame
Start Date: 2025-10-20
Estimated Completion Date: 2029-12-31
Participants
Target number of participants: 3560
Treatments
Experimental: Desflurane group
After routine induction, anesthesia is maintained with inhaled desflurane, with the concentration adjusted as needed to maintain 0.5-2 MAC .Propofol is not used to maintain anesthesia during the whole anesthesia maintenance process, except during cardiopulmonary bypass.
Active_comparator: Propofol group
3-8 mg/kg/h intravenous infusion of propofol to implement total intravenous anesthesia maintenance, without the use of any inhaled anesthetic drugs, can be maintained by intravenous targeted infusion or manual adjustment of intravenous infusion.
Related Therapeutic Areas
Sponsors
Leads: Xijing Hospital