Comparison of Hemodynamic Management by Postural Mobilization Versus Chemical Vasoconstriction Using Noradrenaline Exclusively in Off-pump Coronary Artery Bypass Graft Surgery: A Prospective, Randomized, Comparative, Single-center Study.
Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
This interventional prospective randomized study is designed to compare hemodynamic management using postural mobilization (+/- noradrenaline) versus noradrenaline only in patients undergoing open-heart coronary artery bypass graft (CABG) surgery.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Adult patient
• patient requiring isolated coronary bypass surgery
• Elective procedure or medical emergency
• First cardiac surgery
• Patient with an EF ≥30%
• Mandatory affiliation to a social security system
• Signed informed consent form
• Suspension of renin-angiotensin system inhibitors and angiontensn-neprilysin receptor blockers and sartans the day before surgical procedure
Locations
Other Locations
France
Infirmerie Protestante de Lyon
RECRUITING
Caluire-et-cuire
Contact Information
Primary
SIESS
recherche-clinique@infirmerie-protestante.com
+33 426297927
Time Frame
Start Date: 2025-10-06
Estimated Completion Date: 2027-08
Participants
Target number of participants: 50
Treatments
Experimental: Postural Group: hemodynamic management using postural mobilization (+/- noradrenaline)
In order to manage hemodynamics, postural mobilization will be applied by raising legs passively up to a 45° angle prior to any drug use (noradrenaline). If passive leg raising is not sufficient, noradrenaline will be used to stabilize hemodynamics,.
Active_comparator: Control group: use of noradrenaline only (no postural mobilization)
Noradrenaline will be used to manage hemodynamics. Passive leg raising will not be used in this group
Related Therapeutic Areas
Sponsors
Leads: Infirmerie Protestante de Lyon