Early Initiation of Antiplatelet ThERapy In HeArt TranspLantation: AERIAL Trial
Status: Recruiting
Location: See all (3) locations...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 3
SUMMARY
Cardiac allograft vasculopathy is a common complication affecting heart transplant patients. This condition causes narrowing of the heart arteries leading to graft dysfunction. The research team is investigating whether early antiplatelet therapy post heart transplant can prevent the development of CAV. This study will determine the feasibility of a large multicenter randomized placebo-controlled trial to answer this question.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Heart transplant
• Age ≥18 years
• Able to provide informed consent
Locations
Other Locations
Canada
University of Ottawa Heart Institute
RECRUITING
Ottawa
Toronto General Hospital UHN
RECRUITING
Toronto
St.Pauls Hospital
RECRUITING
Vancouver
Contact Information
Primary
Sharon Chih
schih@ottawaheart.ca
613-696-7000
Backup
Heather Ross
heather.ross@uhn.ca
Time Frame
Start Date: 2021-06-28
Estimated Completion Date: 2029-03
Participants
Target number of participants: 135
Treatments
Placebo_comparator: placebo
Active_comparator: clopidogrel
Active_comparator: aspirin
Related Therapeutic Areas
Sponsors
Collaborators: Canadian Institutes of Health Research (CIHR)
Leads: Ottawa Heart Institute Research Corporation