Effect of Haemoadsorption During Cardiopulmonary Bypass on Patients After Heart Transplantation
Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
To investigate whether the use of haemoadsorption (HA) on cardiopulmonary bypass during heart transplantation (HTX) has an effect on circulating cytokine levels for the first 120 hours after HTX and induces a decreased inflammatory response, increased anti-inflammatory response or immunosuppressive response. Additionally, the influence of HA on primary graft dysfunction, postoperative cerebral dysfunction, postoperative fluid accumulation, renal dysfunction, duration of mechanical ventilation, length of ICU-stay and 30-day mortality should be investigated
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Adult patients undergoing heart transplantation
Locations
Other Locations
Austria
Divison of Cardiac Thoracic Vascular Anaesthesia and Intensive Care, Medical University of Vienna
RECRUITING
Vienna
Contact Information
Primary
Martin H. Bernardi, MD, PhD
martin.bernardi@meduniwien.ac.at
0043140400
Time Frame
Start Date: 2022-09-01
Estimated Completion Date: 2026-06-30
Participants
Target number of participants: 40
Treatments
Active_comparator: Adsorber Group
Surgery with CPB will be performed according to institutional standards, depending on indications and surgical preferences.~For the intervention group (adsorber-group), the CytoSorb adsorber will be installed on the CPB machine in a parallel circuit to the body circulation. The flow through the filter will be driven by a roller pump with 300-400 ml.min-1.
No_intervention: Control
The control group (no-adsorber group) will be treated similarly, but no filter circuit will be installed.
Related Therapeutic Areas
Sponsors
Leads: Medical University of Vienna