Extracellular Vesicles for Rejection Monitoring in Cardiac Transplantation
This study will analyze extracellular vesicle (EV)-derived protein profiles in heart transplantated patients during the first 15 months post-transplantation to investigate, if there are distinct EV-derived proteins or protein patterns that allow early and reliable diagnosis of acute cardiac allograft rejection. Additionally, it will explore temporal changes in the EV-derived protein profile during the early postoperative period irrespective of acute allograft rejection, and will investigate, if there are correlations between EV protein markers and imaging findings.
• Subject is either on the heart transplant waiting list or is still hospitalised following HTx surgery.
• Age of subject is ≥ 18 years.
• Subject is female or male.
• Capacity to consent.
• Signed written informed consent.
• For female subjects:
‣ Confirmed post-menopausal state, defined as amenorrhea for at least 12 months, or
⁃ If being of childbearing potential: Negative highly sensitive urine or serum pregnancy test before inclusion.