Is It Possible To Predict PHLF? - Retrospective Analysis of Gadoxetate MRI Prior To Major Liver Resection

Status: Recruiting
Location: See all (7) locations...
Intervention Type: Diagnostic test
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Post hepatectomy liver failure (PHLF) is one of the most severe complications after liver re-section. Preoperative evaluation of liver function is complicated and imprecise. The volume and function needed for each individual patient is unknown and the methods used for evaluation are uncertain. Preoperative MRI with Gadolinium may give dynamic information regarding liver function correlating with postoperative liver failure. A retrospective analysis will be performed regarding this topic.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Patients who have had a Primovist MRI within 8 weeks before hemihepatectomy or extended hemi-hepatectomy +/- bile duct anastomosis independent of diagnosis.

• Patients with cirrhosis who have had a Primovist MRI within 8 weeks before resection of more than one liver segment

• Patients who had liver volume augmentation with a pre-operative Primovist MRI less than 2 weeks before resection

• Patients who have had a Primovist MRI within 6 weeks be-fore any liver resection where PHLF or death within 90 days occurred.

• \-

Locations
Other Locations
Denmark
Rikshospitalet
RECRUITING
Copenhagen
Finland
Helsingfors Universitetssjukhus
RECRUITING
Helsinki
Norway
Rikshospitalet
RECRUITING
Oslo
Sweden
Sahlgrenska sjukhuset
RECRUITING
Gothenburg
Per Sandström
RECRUITING
Linköping
Karolinska Universitetssjukhuset Huddinge
RECRUITING
Stockholm
Akademiska sjukhuset
RECRUITING
Uppsala
Contact Information
Primary
Per Sandström, Prof
per.sandstrom@liu.se
+46734058581
Backup
Bergthor Bjornsson, MD PhD
bergthor.bjornsson@liu.se
+46101033666
Time Frame
Start Date: 2020-12-29
Estimated Completion Date: 2024-06-30
Participants
Target number of participants: 200
Treatments
Experimental: experimental arm
Single arm study. All patient who had an MRI performed before liver resection is included
Related Therapeutic Areas
Sponsors
Leads: University Hospital, Linkoeping

This content was sourced from clinicaltrials.gov

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