∙ For inclusion in the study, patients should fulfill the following criteria:

⁃ Capable of giving signed informed consent which includes compliance with the requirements and restrictions listed in the informed consent form (ICF) and in this protocol. Written informed consent and any locally required authorization obtained from the patient/legal representative prior to performing any protocol-related procedures, including screening evaluations.

⁃ Diagnosis of unresectable HCC confirmed pathologically or made according to

⁃ American Association for the Study of Liver Diseases (AASLD) practice guideline 2010:

⁃ patients with cirrhosis of any etiology and patients with chronic hepatitis B (HBV) who may not have fully developed cirrhosis, the presence of liver nodule \>1cm and demonstrated in a single contrast-enhanced dynamic imaging \[either computed tomography (CT) or magnetic resonance imaging (MRI)\] of intense arterial uptake and washout in portal venous and delayed phases.

⁃ Adult male or female aged \>18 years at time of study entry

⁃ Eastern Cooperative Oncology Group (ECOG) performance status score of 0 or 1

⁃ Body weight \>30kg

⁃ Evidence of post-menopausal status or negative urinary or serum pregnancy test for female pre-menopausal patients. Women will be considered post-menopausal if they have been amenorrheic for 12 months without an alternative medical cause. The following age-specific requirements apply:

⁃ Women \<50 years of age would be considered post-menopausal if they have been amenorrheic for 12 months or more following cessation of exogenous hormonal treatments and if they have luteinizing hormone and follicle-stimulating hormone levels in the post-menopausal range for the institution or underwent surgical sterilization (bilateral oophorectomy or hysterectomy).

⁃ Women ≥50 years of age would be considered post-menopausal if they have been amenorrheic for 12 months or more following cessation of all exogenous hormonal treatments, had radiation-induced menopause with last menses \>1 year ago, had chemotherapy-induced menopause with last menses \>1 year ago, or underwent surgical sterilization (bilateral oophorectomy, bilateral salpingectomy or hysterectomy).

⁃ Must have a life expectancy of at least 12 weeks

‣ Patient is willing and able to comply with the protocol for the duration of the study including undergoing treatment and scheduled visits and examinations including follow up.

‣ Tumor size 5-25cm and number of lesions ≤3

‣ Portal vein involvement (Vp1-3) is allowed: Vp1, presence of a tumor thrombus distal to, but not within, the second-order branches of the portal vein; Vp2, presence of a tumor thrombus in the second-order branches of the portal vein; Vp3, presence of a tumor thrombus in the first-order branches of the portal vein.

‣ Liver volume minus gross tumor volume (GTV) \> 700cc

‣ Child-Pugh liver function class A-B7

‣ No prior immunotherapy

‣ Subjects with confirmed concomitant HBV infection (defined as HBsAg positive or HBV DNA detectable) that are eligible for inclusion must be treated with antiviral therapy (per local institutional practice) prior to enrollment to ensure adequate viral suppression (HBV DNA \< 2000 IU/mL), must remain on antiviral therapy for the study duration, and continue therapy for 6 months after the last dose of investigational product(s)

‣ At least one measurable lesion according to RECIST v1.1.

∙ Adequate normal organ and marrow function as defined below:

• Haemoglobin ≥ 9.0 g/dL

• Absolute neutrophil count (ANC ≥1.5 (or 1.0) x (\> 1500 per mm\^3)

• Platelet count ≥ 75 x 109/L (\>75,000 per mm\^3)

• Serum bilirubin ≤1.5 x institutional upper limit of normal (ULN).

• AST (SGOT)/ALT (SGPT) ≤2.5 x institutional upper limit of normal unless liver metastases are present, in which case it must be ≤5x ULN

• Measured creatinine clearance (CL) \>45 mL/min or Calculated creatinine clearance CL\>45 mL/min by the Cockcroft-Gault formula (Cockcroft and Gault 1976) or by 24-hour urine collection for determination of creatinine clearance: