Impact of Propofol-Based Total Intravenous Anesthesia Versus Anesthesia With Sevoflurane
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 4
SUMMARY
This is a two-arm, parallel-group randomized clinical trial. Routine perioperative care would be performed in volunteers with primary Hepatocellular carcinoma. The study will enroll approximately 500 volunteers to compare the progression-free or overall survival in patients undergoing elective partial hepatectomy for primary liver tumors between propofol and sevoflurane for the maintenance of anesthesia.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 20
Maximum Age: 80
Healthy Volunteers: f
View:
• Twenty to eighty-year-old.
• ASA class I-III.
• Patients undergoing partial hepatectomy for hepatocellular carcinoma under general anesthesia.
Locations
Other Locations
Taiwan
Kaohsiung Medical University Chung-Ho Memorial Hospital
RECRUITING
Kaohsiung City
Contact Information
Primary
Guan-Yu Chen, M.D.
kindtaco@gmail.com
07-3121101
Time Frame
Start Date: 2022-04-26
Estimated Completion Date: 2027-03-31
Participants
Target number of participants: 500
Treatments
Experimental: Propofol Group
The propofol group was maintained at an effect-site concentration (Ce) of 2.0-4.0 mcg/mL by a target-controlled infusion (TCI) system.
Experimental: Sevoflurane group
The sevoflurane group was maintained via sevoflurane vaporizer between 1% and 3% (target minimum alveolar concentration of 0.7-1.3 MAC).
Related Therapeutic Areas
Sponsors
Leads: Kaohsiung Medical University Chung-Ho Memorial Hospital
Collaborators: Tri-Service General Hospital