Hip Replacement Clinical Trials

Clinical trials related to Hip Replacement Procedure

Reduction of Post-op Pain and Opioid Consumption With the Addition of Methadone in Total Hip Arthroplasty: a Double-blind Randomized Control Trial

Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 3
SUMMARY

This randomized, double-blind controlled trial investigates whether intraoperative intravenous methadone (0.15 mg/kg based on ideal body weight) reduces acute postoperative pain and opioid consumption in patients undergoing elective total hip arthroplasty under spinal anesthesia with mepivacaine. The primary outcome is patient-reported pain on a visual analog scale (VAS) 30-60 minutes after arrival in the post-anesthesia care unit (PACU). Secondary outcomes include opioid use, pain scores over time, incidence of nausea/vomiting, and quality of recovery. A total of 162 subjects will be enrolled at MUSC surgical sites.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 75
Healthy Volunteers: f
View:

• Ages 18-75 years of age

• Undergoing elective primary total hip arthroplasty with mepivacaine in the spinal anesthesia

Locations
United States
South Carolina
Medical University of South Carolina
RECRUITING
Charleston
Contact Information
Primary
Haley Nitchie, MHA
nitchie@musc.edu
843-792-1869
Time Frame
Start Date: 2026-01-12
Estimated Completion Date: 2027-01-31
Participants
Target number of participants: 162
Treatments
Active_comparator: Methadone
Patients will intraoperatively receive methadone 0.15mg/kg IV, based on ideal body weight.
No_intervention: No Methadone
Patients will NOT receive methadone.
Related Therapeutic Areas
Sponsors
Leads: Medical University of South Carolina

This content was sourced from clinicaltrials.gov