Sex Hormone-specific Cardiovascular Risks in the Gut Microbiome-host Axis - A Longitudinal Cohort Study.
Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY
The XCVD study investigates the influence of sex hormones on the composition of the gut microbiome and the possible emergence of cardiovascular risk factors. It will follow 200 healthy transgender individuals for two years during their hormone replacement therapy (HRT) and analyze them for the possible emergence of cardiovascular risk factors in relation to changes in the gut microbiome, metabolome, and immunome. We would also like to phenotype cardiovascular disease.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 50
View:
• Age 18-50
• Language requirements: German, English
• Previous gender hormone replacement therapy (HRT).
• Ability to give consent and written consent to participate.
• Health insurance (for clarification of incidental findings)
Locations
Other Locations
Germany
Experimental and Clinical Research Center, Clinical Research Unit
RECRUITING
Berlin
Contact Information
Primary
Sofia Forslund, Prof. Dr.
sofia.forslund@mdc-berlin.de
+49 30 450540649
Backup
Lajos Marko, Dr.
lajos.marko@charite.de
Time Frame
Start Date: 2022-08-29
Estimated Completion Date: 2027-12-31
Participants
Target number of participants: 200
Related Therapeutic Areas
Sponsors
Collaborators: Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK)
Leads: Charite University, Berlin, Germany