Hormone Replacement Therapy (HRT) Clinical Trials

Clinical trials related to Hormone Replacement Therapy (HRT) Procedure

Hormone Replacement Therapy as an Adjunct Treatment for Adhesive Capsulitis of the Shoulder (Frozen Shoulder) in Peri- and Postmenopausal Women

Status: Recruiting
Location: See location...
Intervention Type: Drug, Behavioral
Study Type: Interventional
Study Phase: Phase 4
SUMMARY

The purpose of this study is to determine the effects of hormone replacement therapy (HRT) in addition to standard treatment on frozen shoulder symptoms in women with age-related changes to their menstrual cycle. Frozen shoulder refers to the condition a doctor diagnosed the participant with regarding shoulder pain, stiffness, and progressive loss of range of motion. Age-related menstrual cycle changes, known as perimenopause and/or menopause, refers to a change or stoppage of monthly menstrual cycles. Other symptoms participants may be experiencing include vaginal dryness, hot flashes, or night sweats. Hormone replacement therapy (HRT) refers to medicine with female hormones in it. For this study, HRT will be in the form of a patch that goes on the skin and a daily oral pill. Participants will be randomly assigned to receive either HRT plus standard care, or only standard care. Follow-up tests will be completed at 6 months of treatment to assess participant progress.

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 40
Healthy Volunteers: f
View:

• Diagnosis of adhesive capsulitis of the shoulder

Locations
United States
California
UCSF Orthopaedic Institute
RECRUITING
San Francisco
Contact Information
Primary
Alexa J Chandler, PhD
alexa.chandler@ucsf.edu
(415) 353-2808
Time Frame
Start Date: 2026-01-15
Estimated Completion Date: 2026-12
Participants
Target number of participants: 60
Treatments
Experimental: Hormone Replacement Therapy plus standard care
Participants will be prescribed HRT for 6 months (estrogen patch and oral progestin) in addition to receiving a steroid injection at the shoulder and referral to physical therapy.
Active_comparator: Standard Care
Participants will receive standard care for frozen shoulder including a steroid injection at the shoulder and referral to physical therapy
Sponsors
Leads: University of California, San Francisco

This content was sourced from clinicaltrials.gov