Uterine Preservation in the Management of Placenta Accreta Spectrum Disorders

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This study for the conservative management of placenta accreta spectrum disorders (PAS), which are a major cause of maternal morbidity and mortality. The most common management strategy for PAS in the United States is a preterm cesarean-hysterectomy. However, accumulating data show that conservative management is safer and is preferred by some patients. In selected participants (n=15) who desire uterine preservation, the investigators provide the option of conservative management, which will be defined as leaving the placenta in the uterus after delivery of the infant. This is a single-arm single-site pilot study where all participants will be carefully monitored during a standard postpartum inpatient stay and with outpatient follow-up until the uterus is empty.

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Healthy Volunteers: f
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• Provision of signed and dated informed consent form.

• Stated willingness to comply with all study procedures and availability for the duration of the study.

• A person with a uterus, age 18 or older

• Currently 16-36 weeks pregnant with an intrauterine gestation

• History of cesarean delivery AND placenta previa OR anterior low-lying placenta AND suspected of having PAS on prenatal imaging (ultrasound/MRI)

• Patients for whom the usual management would be cesarean-hysterectomy.

• Patient desires uterine preservation

• Agreement to adhere to Lifestyle Considerations (see section 5.3) throughout study duration.

Locations
United States
Pennsylvania
Hospital of the University of Pennsylvania
RECRUITING
Philadelphia
Contact Information
Primary
Beth Pineles, MD Phd
beth.pineles@pennmedicine.upenn.edu
267-226-7933
Backup
Meaghan McCabe, MPH
meaghan.mccabe@pennmedicine.upenn.edu
Time Frame
Start Date: 2025-04-21
Estimated Completion Date: 2030-12-31
Participants
Target number of participants: 15
Treatments
Experimental: Uterine preservation
Conservative management of PAS with the inclusion of antibiotics and uterine artery embolization, followed by close monitoring.
Related Therapeutic Areas
Sponsors
Leads: University of Pennsylvania

This content was sourced from clinicaltrials.gov