Effect of Sevoflurane With or Without Intravenous Lidocaine Infusion Versus Propofol Anesthesia on Intracranial Pressure and Cerebral Oxygenation During Laparoscopic Hysterectomy: A Randomized Controlled Study
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
This study will be conducted to evaluate the effects of different anesthetic modalities \[sevoflurane with or without intraoperative lidocaine infusion and Propofol total intravenous anesthesia (TIVA)\] on intracranial pressure (ICP) and cerebral oxygenation assessed by non-invasive methods during laparoscopic hysterectomy (LH).
Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Maximum Age: 65
Healthy Volunteers: f
View:
• Age from 18 to 65 years.
• American Society of Anesthesiologists (ASA) physical status I and Ⅱ.
• Body mass index (BMI) ≤35.
• Females scheduled for laparoscopic hysterectomy.
Locations
Other Locations
Egypt
Tanta University
RECRUITING
Tanta
Contact Information
Primary
Eman A Elrefaey, Master
eman.elrefaey@med.tanta.edu.eg
00201008031402
Time Frame
Start Date: 2025-02-01
Estimated Completion Date: 2027-02-01
Participants
Target number of participants: 90
Treatments
Active_comparator: Propofol group
Patients' anesthesia will be maintained by manually adjusted propofol infusion at a rate of 100-250 mic/kg/min for bispectral index (BIS) maintained between 40-60.
Experimental: Sevoflurane plus lidocaine infusion group
Sevoflurane with monitored anesthesia care (MAC) adjusted to maintain bispectral index (BIS) between 40-60 plus intravenous lidocaine infusion given as 2mg /kg IV bolus before induction then intraoperative infusion by a rate of 2 mg/kg/h until the end of surgery.
Experimental: Sevoflurane group
Patients will receive sevoflurane with monitored anesthesia care (MAC) adjusted to maintain bispectral index (BIS) between 40-60.
Related Therapeutic Areas
Sponsors
Leads: Tanta University