Pancreatic Islet Transplantation in the Anterior Chamber of the Human Eye - a Pilot Study
The overall objective is to establish that transplantation of allogeneic pancreatic islet cells into the anterior chamber of a severely visual impaired diabetic human eye is safe and does not cause ophthalmic or systemic complications. Furthermore, the change in insulin production, glucose control and hypoglycaemia awareness will be assessed.
• Type 1 Diabetes (American Diabetes Association criteria)
• Kidney transplant recipient with ongoing immunosuppression
• At least one eye with extensive loss of vision from hand motion to no light perception due to damage of retina or optic nerve
• Age ≥ 18 years
• Normal cornea with good visualization of the anterior segment
• Patient not eligible or with no wish for standard pancreatic islet into the hepatic portal system or pancreas transplantation