Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2) Infection (COVID-19) in Kidney Transplant Recipients: a Brazilian Multicenter Study

Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY

COVID-19 is the pandemic disease caused by the SARS-CoV-2 coronavirus. It is a highly contagious viral disease, the condition of which main clinical symptoms are characterized by fever and respiratory symptoms. Evidence indicates to worse outcomes in patients with pre-existing diseases, such as diabetes, arterial hypertension, heart disease, pneumopathies, chronic kidney disease, and immunodeficiencies. Recipients of kidney transplants make prolonged use of immunosuppressive drugs to inhibit the acquired immune response, notably the activity of lymphocytes. Due to this potential to modulate the immune and inflammatory response, it is speculated that the clinical and laboratory condition of COVID-19 in these patients is atypical. Preliminary evidence suggests worse outcomes of COVID-19 in immunosuppressed patients, as carriers of cancer. However, information on kidney transplant recipients is insufficient. So far, only reports of the case are available in the literature with different clinical presentations and outcomes. The aim of this study is, therefore, to characterize the demographics, clinical and laboratory conditions, and the outcomes of COVID-19 in kidney transplant recipients in a national multicenter cohort.

Eligibility
Participation Requirements
Sex: All
Healthy Volunteers: f
View:

• Kidney transplant recipients, which may be multi-organ recipients, transplanted in any follow-up period;

• Positive diagnostic test for COVID-19 (detection of viral load, test for detection of antigens or tests for detection of antibodies);

• Outpatient or hospital management;

• Adults and children.

Locations
Other Locations
Brazil
Hospital do Rim
RECRUITING
São Paulo
Contact Information
Primary
Helio Tedesco
heliotedesco@medfarm.com.br
+55 11 5087-8113
Backup
Monica Nakamura
+55 11 5087 8318
Time Frame
Start Date: 2020-05-21
Estimated Completion Date: 2025-04-02
Participants
Target number of participants: 500
Sponsors
Collaborators: Hospital do Rim e Hipertensão
Leads: Helio Tedesco Silva Junior

This content was sourced from clinicaltrials.gov

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