Stratified vs Routine Prophylaxis in Living Kidney Transplantation From HBsAg+ Donors to HBsAg- Recipients
This is a multicenter, prospective, observational study to compare the efficacy and safety of stratified prophylaxis based on donors' and recipients' risk factors vs routine prophylaxis bases on clinical experience in living kidney transplantation from HBsAg+ donors to HBsAg- recipients. The follow-up period was 2 years after renal transplantation. The primary outcome was prevention failure of HBV transmission (any one of HBsAg - → +, HBV DNA - → +, HBeAg - → +, HBeAb - → +, HBcAb - → +, active liver function damage and death in the recipient).
• patients diagnosed with end-stage renal diseases and suitable for living kidney transplantation;
• HBsAg+ donor was the only donor;
• age and sex of donors and recipients were unrestricted;
• ABO compatible or incompatible between the donor and recipient;
• The living donor voluntarily donates one of their kidneys to the recipient free of charge;
• The donor and recipient can understand the purpose and risk of living KT and sign informed consent;
• Ethics committee approved.