Use of Blood Gene Expression Profile and Donor-derived Cell-free DNA to Monitor Response to Treatment After Biopsy-proven Acute Rejection in Pediatric Kidney Transplant Recipients
Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Observational
SUMMARY
The objective of the proposed study is to assess whether a blood biomarker can be used to monitor the response to rejection treatment in pediatric kidney transplant recipients with biopsy-proven acute cellular or antibody mediated rejection. The study hypothesizes that blood gene expression profile and donor-derived cell-free DNA biomarkers (omnigraf) can be used to predict acute rejection and monitor its response to treatment.
Eligibility
Participation Requirements
Sex: All
Maximum Age: 21
Healthy Volunteers: f
View:
• Kidney transplant recipients
• Participants undergoing a for-cause kidney biopsy to rule out graft rejection
• Ages 21 years and less
Locations
United States
Minnesota
University of Minnesota
RECRUITING
Minneapolis
Contact Information
Primary
Ellen Bruno
bruno033@umn.edu
612-301-3608
Time Frame
Start Date: 2023-08-21
Estimated Completion Date: 2026-11-01
Participants
Target number of participants: 30
Related Therapeutic Areas
Sponsors
Leads: University of Minnesota