The Comparison Between Ringer Lactate Solution and Normal Saline with Dextrose Water in the First Week Post-Operative Period of Deceased Donor and Living Donor Kidney Transplantation

Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 3
SUMMARY

This is a randomized controlled pragmatic clinical trial. We aim to evaluate the effect of Ringer lactate solution (RLS) and normal saline solution (NSS) with dextrose water (D5W) on the electrolyte abnormality of kidney transplant recipients (KTR) during the first post-operative week. The problem with using NSS with or without D5W as a standard replacement fluid is the hyperchloremic metabolic acidosis which might compromise the kidney allograft function. A total 60 KTR will be enrolled and randomized to receive either RLS or NSS with D5W. The primary outcome is serum bicarbonate level at day 5 after transplantation. Secondary outcomes include the serum potassium, serum sodium, serum chloride, cytokine panel, and the incidence of delayed graft function.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• A kidney transplant recipient who receives transplant at King Chulalongkorn Memorial Hospital.

• Age \>=18 years

• Both deceased donor and living donor kidney transplantation will be included

Locations
Other Locations
Thailand
Division of Nephrology, Faculty of Medicine, King Chulalongkorn Memorial Hospital
RECRUITING
Bangkok
Contact Information
Primary
Suwasin Udomkarnjananun, MD, PhD
suwasin.u@gmail.com
+66899679885
Time Frame
Start Date: 2024-09-01
Estimated Completion Date: 2026-03-31
Participants
Target number of participants: 60
Treatments
Experimental: Ringer lactate arm
The patient will receive RLS as a replacement fluid for urine output (mL per mL) until the patient have sufficient oral intake and fluid can be removed.
Active_comparator: Normal saline arm with dextrose water
The patient will receive NSS with D5W as a replacement fluid for urine output (mL per mL) until the patient have sufficient oral intake and fluid can be removed.
Related Therapeutic Areas
Sponsors
Leads: King Chulalongkorn Memorial Hospital

This content was sourced from clinicaltrials.gov