Acute Pharmacokinetic-pharmacodynamic Change of Rocuronium After Reperfusion of Renal Graft During Kidney Transplantation

Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Reperfusion of renal graft in kidney transplantation can change the pharmacokinetic-pharmacodynamic (PKPD) parameters of rocuronium. The immediate increase of urine output during surgery may change the PKPD parameters of the drugs, including elimination rate. The goal of this study is to characterize the PKPD model of rocuronium during kidney transplantation and establish a basis for adequate dosage of rocuronium in kidney transplantation. Through PKPD modeling, the changes during reperfusion of the renal graft will be evaluated. Furthermore, the factors related to the changes will be assessed. Adjusting the infusion rate according to the step of kidney transplantation will lead to stable muscle relaxation and fast recovery.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 60
Healthy Volunteers: f
View:

• patients scheduled for elective living donor kidney transplantation

• end stage renal disease with oliguria or anuria

• normal BMI (BMI 18.5 \

• obtained informed consent

Locations
Other Locations
Republic of Korea
Seoul National University Hospital
RECRUITING
Seoul
Contact Information
Primary
Chul-Woo Jung, MD. PhD
spss@dreamwiz.com
82-2-2072-0640
Backup
Eun-Jin Chung, MD
quarkjin@gmail.com
Time Frame
Start Date: 2016-07-01
Estimated Completion Date: 2024-12-31
Participants
Target number of participants: 12
Treatments
Experimental: Rocuronium bolus
rocuronium bromide 1st bolus 0.1mg/kg, rocuronium bromide 2nd bolus 0.4mg/kg
Sponsors
Leads: Seoul National University Hospital

This content was sourced from clinicaltrials.gov