Reduction of Post-op Pain and Opioid Consumption With the Addition of Methadone in Total Knee Arthroplasty: a Double-blind Randomized Control Trial
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 3
SUMMARY
This randomized, double-blind controlled trial investigates whether intraoperative IV methadone (0.15 mg/kg based on ideal body weight) reduces acute postoperative pain and opioid consumption in patients undergoing elective total knee arthroplasty under spinal anesthesia with mepivacaine.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 75
Healthy Volunteers: f
View:
• Ages 18-75 years of age
• Undergoing elective primary total knee arthroplasty with mepivacaine in the spinal anesthesia
Locations
United States
South Carolina
Medical University of South Carolina
RECRUITING
Charleston
Contact Information
Primary
Haley Nitchie, MHA
nitchie@musc.edu
843-792-1869
Time Frame
Start Date: 2026-01-08
Estimated Completion Date: 2027-01-15
Participants
Target number of participants: 162
Treatments
Active_comparator: Methadone
Patients will intraoperatively receive methadone 0.15mg/kg IV, based on ideal body weight.
No_intervention: No Methadone
Patients will NOT receive methadone.
Related Therapeutic Areas
Sponsors
Leads: Medical University of South Carolina