A Prospective, Randomized Trial Utilizing Methadone in the Management of Post-Operative Pain in Total Knee Replacement
The goal of this study is to determine whether one dose of IV methadone given right before surgery will help patients' pain management after a total knee replacement and reduce the amount of pain medications taken in the weeks after surgery.
• Provision of signed and dated informed consent from
• Stated willingness to comply with all study procedures and availability to attend all required visits for the duration of the study.
• Age 21- 75
• Unilateral total knee arthroplasty at Colorado Joint Replacement
• All individuals will be screened for drug use (opioid use, illicit drug use) at their preoperative appointment
• For females of reproductive potential: use of highly effective contraception for at least 1 month prior to screening and agreement to use such a method during study participation.