Leveraging Technology to Improve Medication Adherence in Adolescent and Young Adult Kidney or Liver Transplant Recipients: A Micro-Randomized Trial
Status: Recruiting
Location: See location...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
Can the investigators create an effective way to improve adherence to immunosuppressant medication and reduce rejection, graft loss, and death in adolescents and young adults who have undergone kidney or liver transplantation? The investigators' mobile technology intervention uses real-time electronic pillbox-assessed dose timing and text message prompts to address antirejection medication nonadherence when nonadherence is detected.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 13
Maximum Age: 25
Healthy Volunteers: f
View:
• Adolescents and young adults (13-25 years old) who underwent kidney or liver transplantation at least 6 months prior to enrollment
• Currently prescribed tacrolimus or sirolimus.
Locations
United States
Maryland
Johns Hopkins
RECRUITING
Baltimore
Contact Information
Primary
Cyd Eaton, PhD
ceaton4@jhmi.edu
667-306-6201
Time Frame
Start Date: 2024-03-19
Estimated Completion Date: 2026-11-30
Participants
Target number of participants: 65
Treatments
Experimental: Mobile health (mHealth) text messaging intervention
During baseline (4 weeks), adherence will be monitored daily via electronic pill boxes and no text messages will be sent. After baseline, participants will begin the 12-week micro-randomized trial of the intervention (a within-person study design). During this 12-week micro-randomized trial, daily adherence will be electronically monitored with the electronic pill boxes and participants will be randomized to receive (1) adherence support text messages or (2) no text message after each missed dose, and (1) praise text message or (2) no text message after each on time dose. For 12 months post-intervention, participants will keep using the electronic pill boxes (no text messages will be sent).
Related Therapeutic Areas
Sponsors
Collaborators: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Leads: Johns Hopkins University