Safety and Feasibility of Second-Generation Laryngeal Mask Airway Versus Endotracheal Intubation for Anesthesia in Adult Liver Transplantation: A Multicenter, Prospective, Randomized Controlled Clinical Trial
This prospective, multicenter, randomized controlled trial aims to evaluate the safety and feasibility of second-generation laryngeal mask airway (LMA) management compared with conventional endotracheal intubation (ETT) during general anesthesia in adults undergoing elective liver transplantation. Approximately 100 participants undergoing their first elective liver transplantation will be randomly assigned in a 1:1 ratio to either the LMA group or the ETT group. The study will primarily evaluate a composite endpoint of intraoperative airway-related adverse events, including clinically significant airway leakage, pulmonary aspiration, laryngospasm, bronchospasm, and airway injury. Conversion from LMA to endotracheal intubation, perioperative hemodynamic changes, blood gas measurements, airway placement and removal times, postoperative airway symptoms, pulmonary complications, intensive care unit length of stay, and postoperative hospital length of stay will also be assessed. Participants will be followed during hospitalization and for 3 months after transplantation to evaluate safety, postoperative recovery, rehospitalization, and survival.
• Adults aged 18 to 75 years, regardless of sex.
• Clinical diagnosis of end-stage liver disease, including hepatocellular carcinoma, and scheduled to undergo a first elective allogeneic liver transplantation using the conventional or piggyback technique. Participants with hepatocellular carcinoma must meet the indications for liver transplantation specified in the Chinese Clinical Practice Guidelines for Liver Transplantation for Hepatocellular Carcinoma (2021 Edition). Causes of end-stage liver disease may include, but are not limited to, viral hepatitis-related cirrhosis, alcoholic cirrhosis, and autoimmune liver disease.
• No severe airway abnormality on preoperative assessment, including severe laryngeal malformation, laryngeal tumor, restricted neck movement, mouth opening less than 3 cm, thyromental distance less than 6.5 cm, or Mallampati class IV.
• No history or evidence of a high risk of pulmonary aspiration, including gastric retention, intestinal obstruction, severe gastroesophageal reflux disease, or active upper gastrointestinal bleeding.
• No severe cardiac, pulmonary, or renal organ failure, except for liver disease-related kidney injury, and meeting all of the following criteria:
• Left ventricular ejection fraction of at least 50% on echocardiography performed within 3 months before surgery, without moderate or severe valvular stenosis or regurgitation, severe ventricular hypertrophy or dilation, regional wall-motion abnormalities, or a large pericardial effusion.
• No severe and uncorrectable coronary artery stenosis involving the left main coronary artery or multiple major coronary vessels.
• No acute heart failure or myocardial infarction within 6 months before surgery.
• No severe or uncontrolled chronic obstructive or restrictive pulmonary disease, with FEV1/FVC greater than 70% and vital capacity greater than 80% of the predicted value.
• No hepatopulmonary syndrome or severe pulmonary hypertension at rest, with mean pulmonary artery pressure no greater than 35 mmHg.
• No active pulmonary infection.
• Estimated glomerular filtration rate of at least 60 mL/min/1.73 m2, corresponding to chronic kidney disease stage 1 or 2.
• Body mass index no greater than 30 kg/m2.
• Model for End-Stage Liver Disease score no greater than 30.
• The participant and family members are adequately informed, willing and able to comply with all study procedures, and provide written informed consent.