Clinical Trial of Ex Vivo Lung Perfusion (EVLP) for the Reconditioning of Marginal Donor Lungs for Transplantation.

Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The overall objective of this study is to evaluate the clinical effectiveness of the novel technique of donor EVLP in increasing lung transplant activity by allowing previously unusable donor lungs to be safely used in clinical lung transplantation. Furthermore, to utilize the EVLP technique in research settings thus allowing the evaluation of inflammatory molecules (biomarkers) that would benefit a successful pre-conditioning and increase knowledge of the lungs inflammatory response before transplantation.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 65
Healthy Volunteers: f
View:

• Adult patients (aged 18 years and over).

• Patients already on or added to the active waiting list for first lung transplant.

• Patients providing informed consent for participation in the study at the time of study commencement or time of listing for transplant.

• Patients' re-confirmation informed consent for the study on the day of the lung transplant.

Locations
Other Locations
Canada
Centre Hospitalier de l'Université de Montréal (CHUM)
RECRUITING
Montreal
Contact Information
Primary
Ahmed Menaouar, PhD
ahmed.menaouar.chum@ssss.gouv.qc.ca
514-890-8000
Backup
Basil Nasir, MD
basilsnair@gmail.com
514-890-8000
Time Frame
Start Date: 2014-10
Estimated Completion Date: 2024-12
Participants
Target number of participants: 50
Treatments
No_intervention: Standard Group
Recipients receive standard donor lungs as per current clinical practice.~No experimental procedures will be carried out.
Experimental: EVLP Group
Recipients receive reconditioned EVLP donor lungs and current standard of care for lung transplant is administered.
Related Therapeutic Areas
Sponsors
Leads: Centre hospitalier de l'Université de Montréal (CHUM)
Collaborators: Institut de Recherches Cliniques de Montreal (IRCM), Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Fondation Pour La Recherche en Chirurgie Thoracique De Montreal

This content was sourced from clinicaltrials.gov