Diaphragm Structure and Pathobiology in Patients Being Bridged to Lung Transplant
Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Observational
SUMMARY
This study is designed to characterize the changes in diaphragm structure, function and biology during bridging to lung transplant by mechanical ventilation or extracorporeal life support.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Receiving a respiratory support modality as a bridge to lung transplantation
• Formally listed for transplantation
⁃ \- Undergoing lung transplantation for either obstructive or restrictive lung disease
⁃ \- Undergoing elective thoracic surgery without any prior history of chronic pulmonary parenchymal disease
Locations
Other Locations
Canada
Toronto General Hospital
RECRUITING
Toronto
Contact Information
Primary
Rongyu (Cindy) Jin
rongyu.jin@uhn.ca
416-340-4800
Time Frame
Start Date: 2019-04-01
Estimated Completion Date: 2025-12-30
Participants
Target number of participants: 40
Treatments
Patients undergoing LTx with respiratory failure (cases)
Patients are receiving a respiratory support modality (mechanical ventilation and/or extracorporeal life support) as a bridge to lung transplantation (LTx).
Patients undergoing LTx without prior respiratory support
Patients undergoing lung transplantation but do not require prior bridging respiratory support.
Elective thoracic surgical patients
Patients undergoing elective thoracic surgery for planned lung or esophageal resection.
Related Therapeutic Areas
Sponsors
Leads: University Health Network, Toronto
Collaborators: The Hospital for Sick Children