Treatment Selection and Efficacy of Locally Advanced Breast cancer-a Prospective Randomized Controlled Study
The goal of this clinical trial is to compare the therapeutic effects of chemotherapy followed by surgery and surgery followed by chemotherapy in patients with locally advanced breast cancer（LABC). Patients with LABC will be randomly divided into two groups, each receiving chemotherapy followed by surgery or surgery followed by chemotherapy. The main comparison was between the disease-free survival (DFS) of two groups of patients, with the secondary study endpoint being overall survival (OS); Five year survival; Local recurrence or distant metastasis rate.
• 18-70 year old female
• Patients with locally advanced breast cancer (stage IIIb - IIIc) first diagnosed;
• Clinical diagnosis of breast cancer, or puncture pathology suggests breast cancer;
• After evaluation by experienced clinical physicians, the patient's tumor has the possibility of surgical resection. Specific evaluation indicators include ultrasound assessment of the tumor not surrounding the axillary vein;
• Accept treatment plans including surgery, radiotherapy, and chemotherapy;
• Volunteer to participate in clinical research and sign an informed consent form;
• Willing to undergo follow-up and complete quality of life (EQ-5D series scale and FACT-B scale) and postoperative psychological status (Anxiety/Depression Self Rating Scale) assessments;