The Effect of Adding Amantadine or Duloxetine to Pregabalin on Occurrence of Post Mastectomy Pain Syndrome; Randomized Controlled Study
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
This study aims to evaluate the additive effect of Amantadine or Duloxetine to Pregabalin on development of post mastectomy pain syndrome
Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Maximum Age: 65
Healthy Volunteers: f
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• Age from 18 to 65 years.
• American society of anesthesiologists (ASA) Physical status II, III.
• Body mass index (BMI): (20-40) kg/m2.
• Type of surgery: patients undergoing modified radical mastectomy for breast cancer.
Locations
Other Locations
Egypt
Cairo University
RECRUITING
Cairo
Contact Information
Primary
Hossam H Sayed, MSc
hussamhassan90@gmail.com
00201144692302
Time Frame
Start Date: 2026-02-21
Estimated Completion Date: 2027-01-01
Participants
Target number of participants: 150
Treatments
Active_comparator: Group P (Pregabalin group)
Two hours preoperative patient will receive one capsule of Pregabalin 75 mg (Lyrica 75 mg, Viatris) and) and one placebo tablet and will continue on both of them twice daily for seven days postoperative.
Experimental: Group PA (Pregabalin + Amantadine group)
Two hours preoperative patient will receive one capsule of pregabalin 75 mg (Lyrica 75 mg, Viatris) and one tablet of Amantadine 100 mg (PK-Merz 100 mg, MERZ Pharma) and will continue on both twice daily for seven days postoperative.
Experimental: Group PD (Pregabalin + Duloxetine group)
Two hours preoperative patient will receive one capsule of pregabalin 75 mg (Lyrica 75 mg, Viatris) and one capsule of Duloxetine 30 mg (Cymbatex 30 mg, EVA Pharma) and will continue on both twice daily for seven days postoperative.
Related Therapeutic Areas
Sponsors
Leads: Cairo University