The Functional Role of Cochlear Synaptopathy for Speech Coding in the Brain
In humans, surface electrophysiological recordings of the cochlear nerve in response to a sound stimulus provide information about the cochlear's ability to encode sound. Depending on the stimulus, the fine structure and temporal envelope of the signal will vary, allowing us to determine its characteristics. By phenotyping patients before surgery using subjective and objective audiometric tests, it will be possible to isolate for each patient the moment when the fine structure disappears and when the temporal envelope is effective.
• The following will be included as hearing-impaired patients:
‣ Male or female
⁃ Over 18 and up to 80 years of age
⁃ Normal otoscopic examination
⁃ Scheduled for surgery on the cerebellopontine angle (microvascular decompression)
⁃ With sensorineural hearing loss defined by average hearing thresholds between 21 dB HL and 40 dB HL at 0.5, 1, 2 and 4 kHz
⁃ Affiliated to a social security scheme
⁃ Having read the information note describing the study and having agreed in writing to participate by signing the informed consent form
• Will be included as normal-hearing patients:
‣ Male or female
⁃ Over 18 and up to 80 years of age
⁃ Normal otoscopic examination
⁃ Scheduled for surgery on the cerebellopontine angle (microvascular decompression)
⁃ Free of sensorineural hearing loss, defined by average hearing thresholds of less than or equal to 20 dB HL in tonal air conduction audiometry, bilaterally on the side of the ear undergoing surgery and on the side not undergoing surgery, at 0.5, 1, 2 and 4 kHz
⁃ Affiliated to a social security scheme
⁃ Having read the information note describing the study and having agreed in writing to participate by signing the informed consent form