Advanced Diffusion Imaging in Renal Cancer Patients: Oncologic Control and Renal Functional Reserve
Status: Recruiting
Location: See location...
Intervention Type: Device, Drug
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
The objective of this study is to apply advanced diffusion imaging in a two-pronged assessment of renal mass patients: (1) characterization of lesion malignancy and subtype, and (2) prediction of renal function stability or decline following partial nephrectomy.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 21
Maximum Age: 85
Healthy Volunteers: f
View:
• Renal mass patients scheduled for laparoscopic partial nephrectomy.
• eGFR above 30 ml/min/m2.
• Ages 21 to 85
• Must be willing and able to provide consent.
Locations
United States
New York
NYU Langone Health
RECRUITING
New York
Contact Information
Primary
Nalini Jeet
Nalini.jeet@nyulangone.org
212-263-0228
Backup
Malika Kumbella
Malika.kumbella@nyulangone.org
646-501-0075
Time Frame
Start Date: 2022-12-01
Estimated Completion Date: 2028-12-01
Participants
Target number of participants: 90
Treatments
Experimental: Renal Mass Patients
Patients will be enrolled for 2 MRI visits. These visits will include an approximately 1 hour research MRI scan and a total of between 3 and 5 hours Tc-99m DTPA scan.~In each MRI visit, patients will be scanned for approximately one hour including both standard-of-care clinical sequences and research-based Advanced Diffusion Imaging sequences, on a Prisma 3T MRI scanner. Following the MRI exam or on a day not more than a week after the MRI exam, patients will undergo renal function assessment via Tc-99m DTPA scan and patient's kidneys will be scanned using a gamma camera. Proteinuria will be assessed by standard of care urinalysis of specimens collected at each MRI visit for each patient. Blood test will be performed at each visit to estimate GFR (eGFR) from measurement of serum creatinine.
Related Therapeutic Areas
Sponsors
Leads: NYU Langone Health
Collaborators: National Institutes of Health (NIH)